Markets / Life Sciences

Life Sciences

Flow Cytometry

Improvements in medical research, clinical diagnosis and treatment outcomes rely on the wide availability of biomedical instruments that produce accurate test results rapidly and cost effectively. Thanks to advances in lasers and optics, flow cytometry has become an essential bioanalytical tool to analyze the immune or genetic characteristics of cells. Next generation flow cytometers can rely on the extremely stable, low noise, optical output power of II-VI’s QOMO laser head series to achieve optimum measurement sensitivity and accuracy. This speeds up the measurement throughput, an important factor in reducing cost. The QOMO lasers operate at 488 and 638 nm for dual-wavelength flow cytometry configurations. II-VI’s broad portfolio of products for flow cytometry includes optics and filters for fluorescence spectroscopy in the visible and ultraviolet wavelength ranges, as well as flow cells and precision air and fluid temperature control systems based on thermoelectric coolers.

Fluorescence Imaging

Fluorescence imaging describes a broad range of applications in life sciences, where organic samples to be analyzed are fluorescently tagged, with either a single dye or multiple fluorophores spanning the visible and ultraviolet spectra. The fluorescently labeled samples are then visualized with analytical instruments that rely on high performance optical components and subassemblies. Such systems integrate light sources, optical filters, steering optics, specialized lenses, and detectors to create a sensitive light path that will allow visualization of samples and further down-stream functional studies. II-VI offers a broad range of optical components and subassemblies that work together to form leading edge fluorescent imaging platforms. II-VI’s QOMO lasers operate in the visible range and feature extremely stable, low noise, optical output power that help speed up measurement throughput, which is an important factor in reducing cost. II-VI also supports fully custom quick-turn high performance optical filters that are used to direct and separate the excitation and emission light. II-VI manufactures custom flow cells, objective lenses and precision optical components such as lenses, beam splitters, prisms, waveplates, and patterned optics to address these requirements. II-VI also delivers vertically integrated system solutions. Our new product introduction (NPI) engineering team can provide full optical, mechanical and electrical system support from design to volume manufacturing of fluorescent imaging platforms.

Fluorescence Spectroscopy

Fluorescence spectroscopy is a specific technique used to analyze a sample by illuminating fluorescently labeled molecules and measuring the emission wavelength and energy. Fluorescence measurements provide critical information about the sample characteristics and molecular interactions. Platform examples include spectrofluorometers, filter fluorometers and fluorescence lifetime systems. These instruments rely on a light path that will allow efficient illumination of the sample, collection and low-loss propagation of the emitted signal, and sensitive low-noise detection. II-VI offers a broad range of optical components and subassemblies that work together to form leading edge fluorescent spectroscopy platforms. II-VI’s QOMO lasers operate in the visible range and feature extremely stable, low noise, optical output power that help speed up measurement throughput, which is an important factor in reducing cost. II-VI also supports fully custom quick-turn high performance optical filters such as bandpass filters, dichroics, UV filters, notch filters – all offered in single and multiband formats. Other fluorescence spectroscopy platforms rely on gratings to separate and direct the emission signal. II-VI supports volume and precision grating fabrication with various coating options. II-VI also manufactures custom objective lenses and precision optical components that help direct the light to the detector(s). In cases where precision air and fluid temperature control is required, II-VI can provide custom thermo-electric cooling solutions. II-VI also delivers vertically integrated system solutions. Our new product introduction (NPI) engineering team can provide full optical, mechanical and electrical system support from design to volume manufacturing of fluorescent spectroscopy platforms.

Genome Sequencing

Genome sequencing is a rapidly growing field driving improvements in disease diagnosis, discoveries of new treatments, predictions and preventions of future diseases and the optimization of agriculture plants used to feed our world. The sequencing process depends on very precise temperature control and very high temperature uniformity over large surface areas. II-VI provides thermoelectric cooler based precision temperature control systems that enable proper cooling of reagent systems and exact temperature cycling of DNA to replicate them using the polymerase chain reaction (PCR) process. II-VI also offers low-noise green lasers which are used to excite the DNA to enable florescence imaging. II-VI’s optical filters can be used to direct and separate the excitation and emission light. II-VI supports fully custom quick-turn high performance optical filters. II-VI manufactures custom flow cells, objective lenses and precision optical components such as lenses, beam splitters, prisms, waveplates, and patterned optics to address these requirements. II-VI also delivers vertically integrated system solutions. Our new product introduction (NPI) engineering team can provide full optical, mechanical and electrical system support from design to volume manufacturing of genome sequencing platforms.

Clinical Lasers

The market for lasers in medical and cosmetic applications is growing rapidly. Clinical applications such as benign prostatic hyperplasia (BPH) invasive surgical treatments use diode pumped solid state lasers. Cosmetic treatments like hair removal use direct diode laser heads. II-VI provides one of the broadest portfolios of merchant components for all one micron laser systems designed for clinical applications. These comprise of optics and coatings, including diamond turned freeform optics, acousto-optic modules and fiber-based components for fiber lasers, non-linear optical crystals and neodymium-doped laser crystals for DPSS lasers. Customers can also leverage II-VI’s solutions for passive thermal management using reaction bonded silicon carbide (RB SiC) materials, thermal grade CVD diamond and active thermal management solutions with thermoelectric modules. II-VI’s laser sources range from individual laser diode chips to laser bars and stacks. A broad range of laser diode wavelengths are available to accommodate various pumping schemes for fiber lasers and DPSS lasers, or to match material and tissue absorption characteristics when used in a direct diode laser configurations.